changes What’s driving the process industry

An eye for detail

Wherever a biotechnology system is being installed around the world, chances are American manufacturer Cotter Brothers is among the suppliers. The company is one of the premier specialists in this business. 

Text: Martin Raab
Photos: Jeremy Farrow, Martin Raab
Cotter 1

The list of customers reads like a Who’s Who of the biotech industry. From A for Abbott to Z for Zymogenetics, the Cotter Brothers partner with all of the big names. The family-owned company, located outside of Boston, was one of the very first manufacturers of biopharmaceutical systems and remains a global leader. “Our customers trust us to handle even the most difficult tasks,” says President Randy Cotter Jr. 

The company’s reputation has been built over the years on a foundation of in-depth understanding of bioprocesses and uncompromising quality of the systems made in Danvers, Massachusetts. Cotter Brothers designs, manufactures and installs process skid modules for all stages of biopharmaceutical production.  

Comprehensive offering

On average, two fabrications leave the manufacturing facilities located on the outskirts of Danvers each month. The process skids come in various dimensions, from refrigerator format to the size of an upright container. “We build 50-liter single-use systems as well as 12,000-liter stainless steel bioreactors,” explains Randy Cotter Jr. 

Many of the skids are equipped with measurement technology from Endress+Hauser. “We share the Cotter Brothers’ strategy of clearly aligning with the needs of the industry,” says Ravi Shankar, Industry Manager Life Sciences at Endress+Hauser, USA. “We need partners who understand the requirements of the industry,” confirms Randy Cotter Jr. Last but not least, the two companies are connected through their activities within the Bioprocessing Equipment (BPE) Standards Committee of the reputable American Society of Mechanical Engineers (ASME). 

“We need partners who understand the requirements of the industry.”

Randy Cotter Jr.

President Cotter Brothers

Active from the start

The ASME-BPE guidelines developed by the committee are considered the international standard for building biopharmaceutical manufacturing systems. Many sections of the guidelines carry the handwriting of company founder Randy Cotter Sr. He gained his experience in stainless steel in both the semiconductor and nuclear industries, before he recognized an opportunity to become involved in the nascent biotech industry nearly four decades ago. In delivering his first module in 1981, in essence he was involved from the very start.  

Thoroughly analyzing, understanding and acquiring a command of a subject, Randy Cotter Sr. is an engineer through and through. In the early 80s, there was no blueprint for building production modules for bioprocesses. Even where the requirements were obvious, engineers lacked the experience to implement them. “It was a painstaking learning curve,” recalls the company founder. 

One-of-a-kind expertise

Randy Cotter Sr. tackled many of these challenges systematically. What is the optimal flow rate for liquids? What is the ideal slope for the pipes? What should a weld profile really look like? Randy Cotter Sr. worked tirelessly, in effect performing basic research to achieve technology advances. It was only a few years ago that he obtained funding and worked with industry leaders to understand dead legs in biopharmaceutical piping systems, which can lead to hygiene problems. 

The know-how developed by the family-owned company over the years is unique in the industry. “We scored points with our measurement technology expertise,” reports Alan Senecal, who spent years building up the customer relationship with Cotter Brothers for industrial supplier F.W. Webb, one of the select representatives on which Endress+Hauser’s US sales force is based. “We made ourselves constantly available with consulting and support services. We always delivered the right device for the respective application. And we never left Cotter Brothers high and dry when problems arose.” 

 

Passion for quality 

If the customer has no specific instrumentation requirements, Cotter Brothers recommends products from Endress+Hauser. The company integrates flow, pressure, level and temperature measurement devices into its skids, as well as liquid analysis technology. “We hear time and again that Endress+Hauser has a technological edge,” explains Mark Braatz, who currently manages the relationship with Cotter Brothers for F. W. Webb. “Endress+Hauser’s attention to detail,” as reflected in the introduction of 1.4435-grade stainless steel instruments for life sciences applications for instance, “repeatedly serves as a persuasive selling point.” 

When Endress+Hauser representatives talk about Heartbeat Technology, for self-monitoring of sensors, and Raman analyzers for process control applications, Randy Cotter Sr. takes interest. “Technology transfer is important in our industry,” he says. “We have to be in a position to tell our customers and employees about new innovations, and we have to convey our knowledge to the next generation of engineers,” adds the company founder with confidence. 

 

In close contact 

“One advantage for Endress+Hauser is that we can offer global support,” says Industry Manager Ravi Shankar. Cotter Brothers generates one-third of its revenues with global customers, an area of the business that Randy Cotter Jr. wants to develop further. He knows he can rely on an experienced workforce to carry out his plans – not to mention loyal customers. “The biotech industry is not very forgiving,” says Randy Cotter Jr. “The fact that our customers return to us time and again, that means something in this business!” 

 

What’s behind Cotter Brothers’ market

success?

“We always had the ability to feel the pulse of the industry. We pay attention to our customers and give them what they need. When I started in 1979 it was like a new frontier. It was like when Ford started with the Model A. You wanted to buy a car? It had two doors, four wheels and it was black. And that’s how the industry started with fermenters, bioreactors and chromatography systems. They were always packaged units. As the industry matured, clients also matured and decided they didn’t want that Model A anymore. They wanted a red Model A with three doors and a retractable top. The same thing happened with bioreactors and process equipment. Customers became smarter, and we had to become smarter, too!” 

 

Randy Cotter Sr., company founder and pioneer in the life sciences industry. 

Waches Auge: Eine Mitarbeiterin prüft ein Bauteil.

Watchful eye: an employee inspects a component.

Jahrzehntelange Erfahrung: Cotter Brothers gehört zu den Pionieren im Anlagenbau für die Biotechnologie-Branche.

Decades of experience: Cotter Brothers is among the pioneers of skid module manufacturing for the life sciences industry.

Guter Name: Seit mehr als 30 Jahren sind die Cotters im Geschäft.

Reputable name: the Cotters have been in business for more than 30 years.

Biotech cluster Boston

Boston is a global center for biotechnology. The breeding ground is made up of several world-class universities and leading medical facilities, as well as easy access to venture capital through one of the key financial centers in the United States. The cluster's origins can be traced back nearly four decades when companies such as Biogen and Genzyme evolved from the university scene. The one-time start-ups have long grown into industry leaders. Scores of established pharmaceutical companies also have a presence in the region with their own labs. The biotechnology industry in and around Boston benefits from a constant stream of young scientists and university and clinical research work, as well as an information-sharing network and close cooperation between the companies and various institutes.  

Facts

& Figures

Facts and Figures

Highly specialized provider

Cotter Brothers Corporation, headquartered in Danvers, Massachusetts, near Boston, is a global leader in custom-fabricated process skid systems for biotech manufacturing. The company was originally founded in 1979 by Randy Cotter Sr. and sold to global conglomerate ITT in 2001. Unhappy with the new course, the founder’s three sons – Randy Jr., Tim and David – left the successor company and set up shop again on their own in 2003, bringing a large part of their former staff with them. Today, Cotter Brothers employs 60 people.